Human Neurophysiology Lab

Overview: The Human Neurophysiology Lab seeks to investigate speech (verbal and manual) and non-speech processing across the brain in order to understand underlying patterns of activity that may be linked to hearing, speech, and language disorders. This focus is further centered on the influence of sex and sexuality on cortical activity, as many speech, language, and hearing disorders are more often diagnosed in males. Primarily, electrophysiological and behavioral measures are employed to investigate the nature of these sex and sexuality related differences. The long-term goal of this lab is to extend the electrophysiological techniques to investigate other conditions such as tinnitus and traumatic brain injury (TBI).

Facilities: The Human Neurophysiology Lab is equipped multichannel systems for recording electrophysiological events across the cortex. All testing occurs in a sound shielded booth equipped with monitors for visual stimuli, and earphone system for presentation of auditory stimuli.

People: David Thornton is the laboratory director.

Selected Publications:

Thornton D, Harkrider AW, Jenson D, Saltuklaroglu T. Sex differences in early sensorimotor speech processing for speech discrimination. Scientific Reports. In Review.

Jenson D, Reilly KJ, Harkrider AW, Thornton D, Saltuklaroglu T. Trait related sensorimotor deficits in people who stutter: An EEG investigation of μ rhythm dynamics during spontaneous fluency. Neuroimage Clin. 2018 May 21;19:690-702. doi: 10.1016/j.nicl.2018.05.026. eCollection 2018. PubMed PMID: 29872634; PubMed Central PMCID: PMC5986168.

Saltuklaroglu T, Harkrider AW, Thornton D, Jenson D, Kittilstved T. EEG Mu (µ) rhythm spectra and oscillatory activity differentiate stuttering from non-stuttering adults. Neuroimage. 2017 Jun;153:232-245. doi: 10.1016/j.neuroimage.2017.04.022. Epub 2017 Apr 9. PubMed PMID: 28400266; PubMed Central PMCID: PMC5569894.

Thornton D, Harkrider AW, Jenson D, Saltuklaroglu T. Sensorimotor activity measured via oscillations of EEG mu rhythms in speech and non-speech discrimination tasks with and without segmentation demands. Brain Lang. 2017 Apr 18. pii: S0093-934X(16)30127-4. doi: 10.1016/j.bandl.2017.03.011. [Epub ahead of print] PubMed PMID: 28431691.

Cuellar M, Harkrider AW, Jenson D, Thornton D, Bowers A, Saltuklaroglu T. Time-frequency analysis of the EEG mu rhythm as a measure of sensorimotor integration in the later stages of swallowing. Clin Neurophysiol. 2016 Jul;127(7):2625-35. doi: 10.1016/j.clinph.2016.04.027. Epub 2016 May 5. PubMed PMID: 27291882.

Jenson D, Bowers AL, Harkrider AW, Thornton D, Cuellar M, Saltuklaroglu T. Temporal dynamics of sensorimotor integration in speech perception and production: independent component analysis of EEG data. Front Psychol. 2014 Jul 10;5:656. doi: 10.3389/fpsyg.2014.00656. eCollection 2014. PubMed PMID: 25071633; PubMed Central PMCID: PMC4091311.